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ZIRC
ZFIN ID: ZDB-GENE-010306-4
Gene Name: slit homolog 3 (Drosophila)
Gene Symbol: slit3    Nomenclature History

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Previous Name: zgc:111911

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have Roundabout binding activity and heparin binding activity. Involved in central nervous system projection neuron axonogenesis and negative regulation of axon extension. Predicted to localize to the extracellular space. Is expressed in several structures, including axial mesoderm; fin; nervous system; pectoral fin bud; and presumptive mesoderm. Orthologous to human SLIT3 (slit guidance ligand 3).
Genome Resources: Alliance (1),  Gene:80354 (1),  Ensembl(GRCz11):ENSDARG00000034268 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018893Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027512Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027513Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027514Tg Transgenic Insertion Unknown Unknown DNA
    sa202 Point Mutation Unknown Premature Stop ENU
    sa1569 Point Mutation Unknown Splice Site ENU
    sa9875 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11742 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14755 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30677 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35691 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42392 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • wz07 Insertion Exon 4 Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-slit3 1
    MO1-slit3 N/A 3
    MO2-slit3 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH slit3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH slit3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system projection neuron axonogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 8)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slit3-202 (1)    Ensembl 6146
    ncRNA slit3-002 (1)    Ensembl 1244
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slit3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(slit3:GFP) slit3 GFP Danio rerio 1 1
    Tg2(slit3:GFP) slit3 GFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    slit3 Contained in: [BAC] CH211-51H20 (1) (order this), CH211-245I19 (1) (order this)
    slit3 Encodes: [EST] eu898 (1)
    [cDNA] MGC:111911 (1) (order this), MGC:158201 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131736 (1) 6196 bp
    Genomic GenBank:BX323583 (1) 168098 bp
    Select Tool
    Polypeptide UniProtKB:F1RCV3 (1) 1516 aa
    Sequence Clusters UniGene:111170 (1)
    Sequence Information (all 28)
    ORTHOLOGY for slit3 ( Chr: 14 )
    CITATIONS (47)