Gene

ctsd

ID
ZDB-GENE-010131-8
Name
cathepsin D
Symbol
ctsd Nomenclature History
Previous Names
  • etID16901.18 (1)
  • LAP (1)
  • wu:fb93e11 (1)
  • wu:fj17b09 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have aspartic-type endopeptidase activity. Involved in muscle structure development; response to bacterium; and retinal pigment epithelium development. Predicted to localize to lysosome. Is expressed in several structures, including eye; liver; muscle; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D).
Genome Resources
Note
None
Expression
All Expression Data
14 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctsd Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
neuronal ceroid lipofuscinosis 10 Alliance Ceroid lipofuscinosis, neuronal, 10 610127
Associated With ctsd Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001969 Aspartic peptidase, active site
Domain IPR012848 Aspartic peptidase, N-terminal
Domain IPR033121 Peptidase family A1 domain
Family IPR001461 Aspartic peptidase A1 family
Family IPR033144 Cathepsin D
Homologous_superfamily IPR021109 Aspartic peptidase domain superfamily
Domain Details Per Protein
Protein Length Aspartic peptidase A1 family Aspartic peptidase, active site Aspartic peptidase domain superfamily Aspartic peptidase, N-terminal Cathepsin D Peptidase family A1 domain
UniProtKB:Q1L9E4 398
UniProtKB:Q1L9E5 139
UniProtKB:Q9DD89 399
UniProtKB:Q8JH28 398
UniProtKB:F8W366 145
UniProtKB:Q8AWD9 398
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations