ZFIN ID: ZDB-GENE-010131-8
Gene Name: cathepsin D
Gene Symbol: ctsd    Nomenclature History

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Previous Names: etID16901.18 (1), LAP (1), wu:fb93e11 (1), wu:fj17b09 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have aspartic-type endopeptidase activity. Involved in muscle structure development; response to bacterium; and retinal pigment epithelium development. Predicted to localize to lysosome. Is expressed in several structures, including eye; liver; muscle; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D).
Genome Resources: Alliance (1),  Gene:65225 (1),  Ensembl(GRCz11):ENSDARG00000057698 (1)
GENE EXPRESSION
All Expression Data: 14 figures from 9 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55226]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa36610 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ctsd
    1
    MO1-ctsd N/A 2
    MO2-ctsd N/A 2
    DISEASE ASSOCIATED WITH ctsd HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    neuronal ceroid lipofuscinosis 10 Alliance Ceroid lipofuscinosis, neuronal, 10 610127
    DISEASE ASSOCIATED WITH ctsd VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to bacterium (more)
    Cellular Component lysosome (more)
    Molecular Function aspartic-type endopeptidase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript ctsd-202 (1)    Ensembl 799
    mRNA ctsd-201 (1)    Ensembl 1784
    ncRNA ctsd-003 (1)    Ensembl 635
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ctsd No data available
    MARKER RELATIONSHIPS
    ctsd Contained in: [BAC] CH211-154H20 (1)
    ctsd Contains: [SNP] rs3728906 (1), rs3728907 (1)
    ctsd Encodes: [EST] fb93e11 (1), fj17b09 (1)
    [cDNA] MGC:55226 (1), MGC:77573 (1), MGC:174473 (1), MGC:191989 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131710 (1) 1708 nt
    Genomic GenBank:BX649507 (1) 166185 nt
    Select Tool
    Polypeptide UniProtKB:Q9DD89 (1) 399 aa
    Sequence Information (all 36)
    ORTHOLOGY for ctsd ( Chr: 18 )
    CITATIONS (50)