ZFIN ID: ZDB-GENE-010131-6
Gene Name: midkine b
Gene Symbol: mdkb    Nomenclature History

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Previous Names: mdk2 (1), mdk, cb518 (1), fb79b05, fj33b02, fj48a12, plei2, pleiotrophin 2, wu:fb79b05 (1), wu:fj33b02 (1), wu:fj48a12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have growth factor activity. Involved in brain development; neural crest formation; and positive regulation of neuron differentiation. Localizes to extracellular region. Is expressed in several structures, including nervous system; neural keel; neural rod; neural tube; and presumptive neural plate. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).
Genome Resources: Alliance (1),  Gene:65231 (1),  Ensembl(GRCz11):ENSDARG00000020708 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mi5002 Small Deletion Unknown Unknown CRISPR
sa24609 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32516 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38006 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mdkb 1
    CRISPR2-mdkb
    1
    CRISPR3-mdkb
    1
    CRISPR4-mdkb
    1
    CRISPR5-mdkb
    1
    MO1-mdkb N/A 1
    MO2-mdkb N/A 1
    MO3-mdkb N/A 1
    MO4-mdkb N/A 1
    DISEASE ASSOCIATED WITH mdkb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mdkb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mdkb-201 (1)    Ensembl 1100
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mdkb No data available
    MARKER RELATIONSHIPS
    mdkb Contained in: [BAC] CH73-151M17 (1)
    mdkb Contains: [SNP] rs3729357 (1), rs3729358 (1), rs3729359 (1)
    mdkb Encodes: [EST] cb518 (1) (order this), fb79b05 (1) (order this), fj33b02 (1), fj48a12 (1)
    [cDNA] MGC:73234 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131716 (1) 1018 nt
    Genomic GenBank:CU181898 (1) 122601 nt
    Select Tool
    Polypeptide UniProtKB:A0A0B5JK07 (1) 147 aa
    Sequence Information (all 23)
    ORTHOLOGY for mdkb ( Chr: 25 )
    CITATIONS (43)