ZFIN ID: ZDB-GENE-010126-3
Gene Name: neurotrophic tyrosine kinase, receptor, type 3a
Gene Symbol: ntrk3a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: trkC1 (1), si:ch73-236b16.1

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Involved in central nervous system development and negative regulation of apoptotic process. Predicted to localize to the axon; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in nervous system and otic vesicle. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3).
Genome Resources: Alliance (1),  Gene:568668 (1),  Ensembl(GRCz11):ENSDARG00000077228 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010339Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la023126Tg Transgenic Insertion Unknown Unknown DNA
    sa13864 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24620 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30214 Point Mutation Unknown Premature Stop ENU
    sa38018 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38019 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ntrk3a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ntrk3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
    Domain IPR000483 Cysteine-rich flanking region, C-terminal
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Domain IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
    Family IPR020777 Tyrosine-protein kinase, neurotrophic receptor
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Repeat IPR001611 Leucine-rich repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ntrk3a-202 (1)    Ensembl 13332
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ntrk3a No data available
    MARKER RELATIONSHIPS
    ntrk3a Contained in: [BAC] CH73-309L7 (1), CH211-256N6 (1), DKEY-18E5 (1) (order this), DKEYP-92C6 (1)
    ntrk3a Encodes: [STS] zfish44910-890h03.q1k
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001256664 (1) 3475 nt
    Genomic RefSeq:NW_018395189 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4ITE7 (1) 821 aa
    Sequence Information (all 20)
    ORTHOLOGY for ntrk3a ( Chr: 25 )
    CITATIONS (40)