ZFIN ID: ZDB-GENE-001222-1
Gene Name: visual system homeobox 2
Gene Symbol: vsx2    Nomenclature History

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Previous Names: Vsx-2, alx (1), chx10 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of neural retina development. Predicted to localize to nucleus. Is expressed in nervous system; neural tube; optic cup; and optic vesicle. Human ortholog(s) of this gene implicated in blindness and isolated microphthalmia 2. Orthologous to human VSX2 (visual system homeobox 2).
Genome Resources: Alliance (1),  Gene:796163 (1),  Ensembl(GRCz11):ENSDARG00000005574 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-vsx2 N/A 1
MO2-vsx2 N/A 1
MO3-vsx2 N/A 2
MO4-vsx2 N/A 1
MO5-vsx2 N/A 1
MO6-vsx2 N/A 1
DISEASE ASSOCIATED WITH vsx2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated microphthalmia 2 Alliance Microphthalmia, isolated 2 610093
Microphthalmia with coloboma 3 610092
DISEASE ASSOCIATED WITH vsx2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of transcription by RNA polymerase II (more)
Cellular Component nucleus (more)
Molecular Function sequence-specific DNA binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA vsx2-201 (1)    Ensembl 1720
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-vsx2 polyclonal IgG Sheep IHC Exalpha Biologicals, Inc
1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM vsx2
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(vsx2:GAL4-VP16) vsx2 GAL4VP16 Danio rerio 1 5
Tg(vsx2:GFP) vsx2 GFP Danio rerio 1 1
Tg(vsx2:GFP-CAAX) vsx2 CAAXGFP Danio rerio 2 3
Tg(vsx2:Kaede) vsx2 Kaede Danio rerio 1 10
Tg(vsx2:LOXP-DsRed-LOXP-GFP) vsx2 DsRedGFP Danio rerio 1 13
TgBAC(vsx2:EGFP) vsx2 EGFP Danio rerio 1 35
TgBAC(vsx2:GAL4FF) vsx2 GAL4FF Danio rerio 1 8
MARKER RELATIONSHIPS
vsx2 Contained in: [BAC] DKEY-202B14 (1) (order this)
vsx2 Encodes: [cDNA] MGC:66294 (1), MGC:85859 (1), MGC:191377 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131462 (1) 1712 nt
Genomic GenBank:BX005320 (1) 142827 nt
Select Tool
Polypeptide UniProtKB:O42477 (1) 393 aa
Sequence Information (all 23)
ORTHOLOGY for vsx2 ( Chr: 17 )
CITATIONS (74)