Gene

vsx2

ID
ZDB-GENE-001222-1
Name
visual system homeobox 2
Symbol
vsx2 Nomenclature History
Previous Names
  • Vsx-2
  • alx (1)
  • chx10 (1)
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of neural retina development. Predicted to localize to nucleus. Is expressed in nervous system; neural tube; optic cup; and optic vesicle. Human ortholog(s) of this gene implicated in blindness and isolated microphthalmia 2. Orthologous to human VSX2 (visual system homeobox 2).
Genome Resources
Note
None
Expression
All Expression Data
60 figures from 30 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vsx2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated microphthalmia 2 Alliance Microphthalmia, isolated 2 610093
Microphthalmia with coloboma 3 610092
Associated With vsx2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003654 OAR domain
Domain IPR023339 CVC domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length CVC domain Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily OAR domain
UniProtKB:O42477 393
UniProtKB:F1QQE7 372
UniProtKB:B2GP41 372
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-vsx2 polyclonal IgG Sheep
  • IHC
Exalpha Biologicals, Inc
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations