ZFIN ID: ZDB-GENE-001222-1
Gene Name: visual system homeobox 2
Gene Symbol: vsx2
Sequence Ontology ID : SO:0000704

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Previous Names: Vsx-2, alx (1), chx10 (1)

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Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 53 figures from 25 publications
Directly Submitted Expression Data: 5 figures (9 images) from Thisse et al., 2004 [MGC:66294]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth)
  CiD, ciliary marginal zone, ciliary marginal zone cell, ciliary marginal zone somatic stem cell (all 30) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents: MO1-vsx2 (1), MO2-vsx2 (1), MO3-vsx2 (1), MO4-vsx2 (1), MO5-vsx2 (1) (all 6) expand
PHENOTYPE
Data: 5 figures from 3 publications
Observed in: eye, head, Muller cell, retina cell proliferation involved in compound eye morphogenesis (all 6) expand
DISEASE ASSOCIATED WITH vsx2 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
isolated microphthalmia 2 Microphthalmia, isolated 2 610093
microphthalmia Microphthalmia, isolated 2 610093
Microphthalmia with coloboma 3 610092
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of transcription from RNA polymerase II promoter (more)
Cellular Component nucleus (more)
Molecular Function sequence-specific DNA binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003654 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR023339 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • PROSITE:PS50803 (1)
  • PROSITE:PS51496 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF03826 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA vsx2-001 (1) 1720
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-vsx2 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM vsx2
    Tg(vsx2:GAL4-VP16), tg(vsx2:gfp), Tg(vsx2:GFP-CAAX), Tg(vsx2:Kaede), Tg(vsx2:LOXP-DsRed-LOXP-GFP) (all 7) expand
    MARKER RELATIONSHIPS
    vsx2Contained in: [BAC] DKEY-202B14 (1) (order this)
    vsx2Encodes: [cDNA] MGC:66294 (1) (order this), MGC:85859 (1) (order this), MGC:191377 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131462 (1) 1712bp
    Genomic GenBank:BX005320 (1) 142827bp
    Select Tool
    Polypeptide UniProtKB:O42477 (1) 393aa
    Sequence Clusters UniGene:75766 (1)
    Sequence Information (all 24)
    OTHER vsx2 GENE PAGES
  • Alliance (1)
  • Gene:796163 (1)
  • VEGA:OTTDARG00000024821 (1)
  • Ensembl(GRCz10):ENSDARG00000005574 (1)
  • ORTHOLOGY for vsx2 (Chr: 17)
    CITATIONS (65)