ZFIN ID: ZDB-GENE-001212-6
Gene Name: ATPase Na+/K+ transporting subunit alpha 2a
Gene Symbol: atp1a2a    Nomenclature History

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Previous Names: atp[a]2 (1), cb702 (1), fa10d04, fa10d05, wu:fa10d05 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have sodium:potassium-exchanging ATPase activity. Involved in several processes, including animal organ development; heart contraction; and thigmotaxis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Is expressed in several structures, including Kupffer's vesicle; brain; heart; musculature system; and pronephric duct. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2).
Genome Resources: Alliance (1),  Gene:64609 (1),  Ensembl(GRCz11):ENSDARG00000010472 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023718Tg Transgenic Insertion Unknown Unknown DNA
sa9321 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11860 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18737 Point Mutation Unknown Premature Stop ENU
    sa33010 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33011 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39924 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39925 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-atp1a2a N/A 3
    MO2-atp1a2a N/A 1
    DISEASE ASSOCIATED WITH atp1a2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    alternating hemiplegia of childhood Alliance Alternating hemiplegia of childhood 1 104290
    familial hemiplegic migraine 2 Alliance Migraine, familial basilar 602481
    Migraine, familial hemiplegic, 2 602481
    DISEASE ASSOCIATED WITH atp1a2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atp1a2a-201 (1)    Ensembl 3907
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp1a2a No data available
    MARKER RELATIONSHIPS
    atp1a2a Contained in: [BAC] DKEYP-35B8 (1)
    atp1a2a Encodes: [EST] cb702 (2), fa10d04 (1), fa10d05 (1)
    [cDNA] MGC:194325 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131683 (1) 3889 nt
    Genomic GenBank:BX294126 (1) 179476 nt
    Select Tool
    Polypeptide UniProtKB:B0S5Q5 (1) 1017 aa
    Sequence Information (all 23)
    ORTHOLOGY for atp1a2a ( Chr: 2 )
    CITATIONS (35)