ZFIN ID: ZDB-GENE-001205-4
Gene Name: cathepsin K
Gene Symbol: ctsk
Sequence Ontology ID : SO:0000704

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Previous Names: etID33526.16 (1), wu:fa95f03, wu:fb08b05, zgc:110367

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(Including Attributions)
Location: Chr: 16 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have cysteine-type endopeptidase activity; involved in bone development, cartilage development, and response to mechanical stimulus; predicted to localize to the extracellular space and  ...
GENE EXPRESSION
All Expression Data: 15 figures from 8 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2004 [MGC:110367]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents:
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ctsk HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
pycnodysostosis Pycnodysostosis 265800
DISEASE ASSOCIATED WITH ctsk VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to mechanical stimulus (more)
Cellular Component extracellular space (more)
Molecular Function cysteine-type peptidase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000169 (1)
  • InterPro:IPR000668 (1)
  • InterPro:IPR013128 (1)
  • InterPro:IPR013201 (1)
  • InterPro:IPR015644 (1)
  • InterPro:IPR025660 (1)
  • InterPro:IPR025661 (1)
  • InterPro:IPR038765 (1)
  • InterPro:IPR039417 (1)
  • PROSITE:PS00139 (1)
  • PROSITE:PS00639 (1)
  • PROSITE:PS00640 (1)
  • Pfam:PF00112 (1)
  • Pfam:PF08246 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ctsk-201 (1) 1639
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ctsk
    MARKER RELATIONSHIPS
    ctskContained in: [BAC] CH211-113G11 (1) (order this), DKEY-30O16 (1) (order this)
    ctskEncodes: [EST] fa95f03 (1), fb08b05 (1)
    [cDNA] MGC:110367 (1) (order this), MGC:191754 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001017778 (1) 1595bp
    Genomic GenBank:BX248517 (1) 201353bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q8A0 (1) 333aa
    Sequence Clusters UniGene:76224 (1)
    Sequence Information (all 25)
    OTHER ctsk GENE PAGES
  • Alliance (1)
  • Gene:550475 (1)
  • VEGA:OTTDARG00000018948 (1)
  • Ensembl(GRCz11):ENSDARG00000040251 (2)
  • ORTHOLOGY for ctsk (Chr: 16)
    CITATIONS (43)