ZFIN ID: ZDB-GENE-001205-4
Gene Name: cathepsin K
Gene Symbol: ctsk    Nomenclature History

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Previous Names: etID33526.16 (1), wu:fa95f03, wu:fb08b05, zgc:110367

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity. Involved in bone development; cartilage development; and response to mechanical stimulus. Predicted to localize to the extracellular space and lysosome. Human ortholog(s) of this gene implicated in pycnodysostosis. Is expressed in several structures, including cardiovascular system; head; lateral line system; mesoderm; and pectoral fin. Orthologous to human CTSK (cathepsin K).
Genome Resources: Alliance (1),  Gene:550475 (1),  Ensembl(GRCz11):ENSDARG00000040251 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-ctsk N/A 3
MO2-ctsk N/A 1
PHENOTYPE
Data: Fig. 7 from Flanagan-Steet et al., 2018
Observed in:
DISEASE ASSOCIATED WITH ctsk HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
pycnodysostosis Alliance Pycnodysostosis 265800
DISEASE ASSOCIATED WITH ctsk VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to mechanical stimulus (more)
Cellular Component extracellular space (more)
Molecular Function cysteine-type peptidase activity (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Active_site IPR000169 Cysteine peptidase, cysteine active site
Active_site IPR025660 Cysteine peptidase, histidine active site
Active_site IPR025661 Cysteine peptidase, asparagine active site
Domain IPR000668 Peptidase C1A, papain C-terminal
Domain IPR013201 Cathepsin propeptide inhibitor domain (I29)
Domain IPR039417 Papain-like cysteine endopeptidase
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ctsk-201 (1)    Ensembl 1639
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-ctsk polyclonal IgG Rabbit IHC Abcam plc
3
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ctsk
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
TgBAC(ctsk:Citrine) ctsk Citrine Danio rerio 1 5
MARKER RELATIONSHIPS
ctsk Contained in: [BAC] CH211-113G11 (1), DKEY-30O16 (1) (order this)
ctsk Encodes: [EST] fa95f03 (1), fb08b05 (1)
[cDNA] MGC:110367 (1), MGC:191754 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001017778 (1) 1595 nt
Genomic GenBank:BX248517 (1) 201353 nt Blast at MegaBLAST
Polypeptide UniProtKB:F1Q8A0 (1) 333 aa
Sequence Information (all 24)
ORTHOLOGY for ctsk ( Chr: 16 )
CITATIONS (50)