Gene

ctsk

ID
ZDB-GENE-001205-4
Name
cathepsin K
Symbol
ctsk Nomenclature History
Previous Names
  • etID33526.16 (1)
  • wu:fa95f03
  • wu:fb08b05
  • zgc:110367
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within bone development; cartilage development; and response to mechanical stimulus. Predicted to be located in apical plasma membrane and extracellular region. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including cardiovascular system; head; lateral line system; mesoderm; and pectoral fin. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Flanagan-Steet et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctsk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
pycnodysostosis Alliance Pycnodysostosis 265800
Associated With ctsk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR000169 Cysteine peptidase, cysteine active site
Active_site IPR025660 Cysteine peptidase, histidine active site
Active_site IPR025661 Cysteine peptidase, asparagine active site
Domain IPR000668 Peptidase C1A, papain C-terminal
Domain IPR013201 Cathepsin propeptide inhibitor domain (I29)
Domain IPR039417 Papain-like cysteine endopeptidase
Family IPR015644 Peptidase C1A, cathepsin K
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length Cathepsin propeptide inhibitor domain (I29) Cysteine peptidase, asparagine active site Cysteine peptidase, cysteine active site Cysteine peptidase, histidine active site Papain-like cysteine endopeptidase Papain-like cysteine peptidase superfamily Peptidase C1A, cathepsin K Peptidase C1A, papain C-terminal
UniProtKB:Q568D6 333
UniProtKB:F8QXP4 284
UniProtKB:F1Q8A0 333
UniProtKB:F8QXP3 284
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ctsk polyclonal IgG Rabbit
  • IHC
Abcam plc
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations