ZFIN ID: ZDB-GENE-001205-3
Gene Name: GTP cyclohydrolase 2
Gene Symbol: gch2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: gch, camembert (1), fb51g02, gch1b (1), unm_vc44, wu:fb51g02 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have GTP binding activity; GTP cyclohydrolase I activity; and zinc ion binding activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Predicted to localize to cytoplasm. Is expressed in head; neural crest; pigment cell; trunk; and xanthoblast. Human ortholog(s) of this gene implicated in bipolar disorder; dystonia; and dystonia 5. Orthologous to human GCH1 (GTP cyclohydrolase 1).
Genome Resources: Alliance (1),  Gene:64263 (1),  Ensembl(GRCz11):ENSDARG00000099101 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
vc44 Complex Unknown Unknown SPONTANEOUS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-gch2
2
CRISPR2-gch2
2
DISEASE ASSOCIATED WITH gch2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dystonia 5 Alliance Dystonia, DOPA-responsive, with or without hyperphenylalaninemia 128230
Hyperphenylalaninemia, BH4-deficient, B 233910
DISEASE ASSOCIATED WITH gch2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process xanthophore differentiation (more)
Cellular Component cytoplasm (more)
Molecular Function GTP cyclohydrolase I activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gch2-201 (1)    Ensembl 1932
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gch2 No data available
MARKER RELATIONSHIPS
gch2 Contained in: [BAC] CH211-79A21 (1)
gch2 Encodes: [EST] eu499 (1), fb51g02 (1)
[cDNA] MGC:86587 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131667 (1) 1876 nt
Genomic GenBank:CR385067 203410 nt Blast at MegaBLAST
Polypeptide UniProtKB:Q6IQV5 (1) 240 aa
Sequence Information (all 18)
ORTHOLOGY for gch2 ( Chr: 12 )
CITATIONS (53)