ZFIN ID: ZDB-GENE-001103-2
Gene Name: SRY-box transcription factor 9b
Gene Symbol: sox9b    Nomenclature History

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Previous Names: fb18d01, wu:fb18d01 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including animal organ development; embryonic pectoral fin morphogenesis; and iridophore differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in 46 XY gonadal dysgenesis and campomelic dysplasia. Is expressed in several structures, including digestive system; head; nervous system; neural crest; and pleuroperitoneal region. Orthologous to human SOX9 (SRY-box transcription factor 9).
Genome Resources: Alliance (1),  Gene:60642 (1),  Ensembl(GRCz11):ENSDARG00000043923 (2)
GENE EXPRESSION
All Expression Data: 103 figures from 77 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [MGC:76805]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh313 Point Mutation Unknown Premature Stop ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40193 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sox9b_unrecovered Point Mutation Unknown Unknown ENU
    sox9b_unspecified Unspecified Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sox9b N/A 1
    MO2-sox9b N/A 4
    MO3-sox9b N/A 6
    MO4-sox9b N/A 1
    MO5-sox9b N/A 3
    MO6-sox9b N/A 3
    MO7-sox9b N/A 2
    DISEASE ASSOCIATED WITH sox9b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    campomelic dysplasia Alliance Acampomelic campomelic dysplasia 114290
    Campomelic dysplasia 114290
    Campomelic dysplasia with autosomal sex reversal 114290
    DISEASE ASSOCIATED WITH sox9b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process inner ear development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR009071 High mobility group box domain
    Domain IPR022151 Sox developmental protein N-terminal
    Family IPR029548 Transcription factor SOX-9
    Homologous_superfamily IPR036910 High mobility group box domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sox9b-201 (1)    Ensembl 3419
    sox9b-202 (1)    Ensembl 864
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-sox9b Rabbit IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sox9b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-.9sox9b:EGFP) sox9b EGFP Danio rerio 1 1
    Tg(-.56sox9b:EGFP) sox9b EGFP Danio rerio 1 1
    Tg(-1.8sox9b:EGFP) sox9b EGFP Danio rerio 1 1
    Tg(-1.88sox9b:EGFP) sox9b EGFP Danio rerio 1 1
    Tg(-2.4sox9b:EGFP) sox9b EGFP Danio rerio 1 1
    tg(myl7:dnsox9b-2a-trfp) myl7 2ARFPsox9b Danio rerio 1 1
    Tg(sox9b:EGFP) sox9b EGFP Danio rerio 1 5
    tg(uas:dnsox9b-2a-trfp,cryaa:mcherry) cryaaUAS 2AmCherryRFPsox9b Danio rerio 1 1
    tg(uas:dnsox9b-2a-trfp,myl7:egfp) myl7UAS 2AEGFPRFPsox9b Danio rerio 1 1
    Tg(ubb:LOXP-ECFP-LOXP-dnsox9b-2A-mCherry) ubb 2AECFPLOXPmCherrysox9b Danio rerio 1 1
    Tg(ubb:LOXP-ECFP-LOXP-sox9b-2A-mCherry) ubb 2AECFPLOXPmCherrysox9b Danio rerio 1 2
    TgFOS(sox9b:Citrine) sox9b Citrine Danio rerio 1 2
    MARKER RELATIONSHIPS
    sox9b Contained in: [Fosmid] CH1073-175H21 (1)
    sox9b Encodes: [EST] fb18d01 (1)
    [cDNA] MGC:76805 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131644 (1) 1916 nt
    Genomic GenBank:CU855796 (1) 35870 nt
    Select Tool
    Polypeptide UniProtKB:Q9DFH1 (1) 407 aa
    Sequence Information (all 23)
    ORTHOLOGY for sox9b ( Chr: 3 )
    CITATIONS (187)