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ZIRC
ZFIN ID: ZDB-GENE-001103-1
Gene Name: SRY-box transcription factor 9a
Gene Symbol: sox9a    Nomenclature History

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Previous Names: jef (1), jellyfish, wu:fj17b12, zgc:111921

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits chromatin binding activity. Involved in cartilage morphogenesis; embryonic morphogenesis; and glial cell differentiation. Localizes to the cytoplasm. Human ortholog(s) of this gene implicated in 46 XY gonadal dysgenesis and campomelic dysplasia. Is expressed in several structures, including brain; ectoderm; head; reproductive system; and skeletal system. Orthologous to human SOX9 (SRY-box transcription factor 9).
Genome Resources: Alliance (1),  Gene:60641 (1),  Ensembl(GRCz11):ENSDARG00000003293 (2)
GENE EXPRESSION
All Expression Data: 165 figures from 126 publications
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1134Tg Transgenic Insertion Acceptor Splice Site of Exon 2 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sox9a_unspecified Unspecified Unknown Unknown
    tw37 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zc81Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sox9a N/A 2
    MO2-sox9a N/A 6
    MO3-sox9a N/A 4
    MO4-sox9a N/A 1
    MO5-sox9a N/A 1
    MO6-sox9a N/A 1
    MO7-sox9a N/A 1
    DISEASE ASSOCIATED WITH sox9a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    campomelic dysplasia Alliance Acampomelic campomelic dysplasia 114290
    Campomelic dysplasia 114290
    Campomelic dysplasia with autosomal sex reversal 114290
    DISEASE ASSOCIATED WITH sox9a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process inner ear development (more)
    Cellular Component cytoplasm (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 22)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sox9a-201 (1)    Ensembl 1784
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-sox9 monoclonal IgG2a , k Mouse IHC Abcam plc
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sox9a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.4shha-E1:GFP) shhasox9a GFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    sox9a Contained in: [BAC] CH73-314D5 (1) (order this)
    sox9a Encodes: [EST] fj17b12
    [cDNA] MGC:111921 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131643 (1) 1790 bp
    Genomic GenBank:CU074420 (1) 97020 bp
    Select Tool
    Polypeptide UniProtKB:Q9DFH2 (1) 462 aa
    Sequence Clusters UniGene:80814 (1)
    Sequence Information (all 24)
    ORTHOLOGY for sox9a ( Chr: 12 )
    CITATIONS (250)