ZFIN is now using GRCz12tu for Genomic Data
Gene
cd74a
- ID
- ZDB-GENE-000901-1
- Name
- CD74 molecule, major histocompatibility complex, class II invariant chain a
- Symbol
- cd74a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable MHC class II protein binding activity; cytokine receptor activity; and macrophage migration inhibitory factor binding activity. Acts upstream of or within several processes, including T cell activation involved in immune response; dendritic cell antigen processing and presentation; and neuromast development. Located in cell surface. Is expressed in dendritic cell; otic vesicle; pectoral fin bud; pharyngeal arch; and sensory system. Orthologous to human CD74 (CD74 molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77643 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000716 | Thyroglobulin type-1 |
| Domain | IPR015386 | MHC class II-associated invariant chain/CLIP, MHC II-interacting |
| Family | IPR043530 | HLA class II histocompatibility antigen, gamma subunit |
| Family | IPR051950 | Developmental regulator and protease inhibitor |
| Homologous_superfamily | IPR036857 | Thyroglobulin type-1 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Developmental regulator and protease inhibitor | HLA class II histocompatibility antigen, gamma subunit | MHC class II-associated invariant chain/CLIP, MHC II-interacting | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PUT2 | InterPro | 237 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers