Gene

nkx2.4b

ID

ZDB-GENE-000830-1

Name

NK2 homeobox 4b

Symbol

nkx2.4b Nomenclature History

Previous Names

nk2.1a (1)
nkx2.1 (1)
nkx2.1a
nkx2.4a (1)
titf1
titf1a (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hypothalamus development and thyroid gland development. Predicted to be active in nucleus. Is expressed in several structures, including endocrine system; forebrain; neural keel; neural plate; and swim bladder. Orthologous to human NKX2-4 (NK2 homeobox 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

77 figures from 49 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nkx2.4b Human Ortholog

No data available

Associated With nkx2.4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR020479	Homeobox domain, metazoa
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily