ZFIN Gene: nkx2.4b

ZFIN ID: ZDB-GENE-000830-1

ZFIN ID: ZDB-GENE-000830-1

Gene Name:

NK2 homeobox 4b

Gene Symbol:

nkx2.4b

Sequence Ontology ID :

SO:0000704

Previous Names:

nk2.1a (1), nkx2.1 (1), nkx2.1a, nkx2.4a (1), titf1, titf1a (1)

Location:

Chr: 20 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in hypothalamus development and thyroid gland ...

GENE EXPRESSION
All Expression Data:	73 figures from 46 publications
Wild-type Stages, Structures:	Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
	anterior chamber swim bladder brain cardiac muscle cell caudal tuberculum diencephalon dopaminergic neuron diencephalon ductus communicans forebrain ventral region forebrain forebrain neural keel forebrain neural plate hypothalamus anterior region hypothalamus dopaminergic neuron hypothalamus posterior region hypothalamus intermediate hypothalamus neural keel neural plate pharyngeal endoderm pharynx posterior region posterior chamber swim bladder swim bladder telencephalon thyroid follicle thyroid primordium unspecified
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa23811	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE No data available

DISEASE ASSOCIATED WITH nkx2.4b HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH nkx2.4b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	hypothalamus development (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 10)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001356 (1) InterPro:IPR009057 (1) InterPro:IPR017970 (1) InterPro:IPR020479 (1)	PROSITE:PS00027 (1) PROSITE:PS50071 (1)	Pfam:PF00046 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	nkx2.4b-201 (1)	1151	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM nkx2.4b No data available

MARKER RELATIONSHIPS

nkx2.4bContained in:	[BAC] DKEY-165F9 (1) (order this)
nkx2.4bEncodes:	[cDNA] MGC:193896 (1) (order this), MGC:193913 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131589 (1)	1175bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CT573061 (1)	79800bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A5WVY6 (1)	307aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:82318 (1)

Sequence Information (all 19)

OTHER nkx2.4b GENE PAGES

Alliance (1)

Gene:58112 (1)

VEGA:OTTDARG00000023367 (1)

Ensembl(GRCz11):ENSDARG00000104107 (1)

ORTHOLOGY for nkx2.4b (Chr: 20)

CITATIONS (101)

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