ZFIN ID: ZDB-PUB-000824-17
Expression of nk2.1a during early development of the thyroid gland in zebrafish
Rohr, K.B. and Concha, M.L.
Date: 2000
Source: Mechanisms of Development   95(1-2): 267-270 (Journal)
Registered Authors: Concha, Miguel, Rohr, Klaus
Keywords: thyroid development; TTF-1; nk2.1; Titf-1; fate map; photoactivated fluorescein
MeSH Terms:
  • Animals
  • Gene Expression Regulation, Developmental*
  • Homeodomain Proteins/genetics
  • Nuclear Proteins/genetics*
  • Thyroid Gland/embryology*
  • Thyroid Gland/physiology
  • Transcription Factors/genetics*
  • Zebrafish/embryology*
  • Zebrafish/genetics*
PubMed: 10906475 Full text @ Mech. Dev.
We show here that a zebrafish orthologue of the Thyroid Transcription Factor-1 (TTF-1), nk2.1a, is expressed in the developing thyroid gland. Using a fate mapping approach we found that an early nk2.1a expression domain in the endoderm adjacent to the heart follows morphogenetic movements of the lower jaw, ending up in the region in which the mature thyroid gland is located. We therefore suggest that nk2.1a labels the thyroid precursor cells from somitogenesis stages onwards.