Gene
zic2a
- ID
- ZDB-GENE-000710-4
- Name
- zic family member 2 (odd-paired homolog, Drosophila), a
- Symbol
- zic2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; neural tube formation; and regulation of signal transduction. Predicted to localize to nucleus. Is expressed in several structures, including anterior neural keel; central nervous system; ectoderm; neural plate; and presumptive structure. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb851 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Holoprosencephaly 5 | 609637 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ZIC protein, zinc finger domain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
|
UniProtKB:Q9IAT0
|
445 |
Interactions and Pathways
No data available
Plasmids
- Addgene:E1b-GFP-Tol2-Gateway dre SE-zic2a L
- Addgene:E1b-GFP-Tol2-Gateway dre SE-zic2a M
- Addgene:E1b-GFP-Tol2-Gateway dre SE-zic2a N
- Addgene:E1b-GFP-Tol2-Gateway dre SE-zic2a O
- Addgene:E1b-GFP-Tol2-Gateway dre SE-zic2a P
- Addgene:E1b-GFP-Tol2-Gateway dre SE-zic2a Q
- Addgene:E1b-GFP-Tol2-Gateway dre SE-zic2a R
- Addgene:E1b-GFP-Tol2-Gateway dre SE-zic2a S