ZFIN ID: ZDB-GENE-000710-4
Gene Name: zic family member 2 (odd-paired homolog, Drosophila), a
Gene Symbol: zic2a    Nomenclature History

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Previous Names: zic2.1 (1), zic2 (1), cb851 (1), fb26a03, wu:fb26a03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; neural tube formation; and regulation of signal transduction. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Is expressed in several structures, including anterior neural keel; central nervous system; ectoderm; neural plate; and presumptive structure. Orthologous to human ZIC2 (Zic family member 2).
Genome Resources: Alliance (1),  Gene:58077 (1),  Ensembl(GRCz11):ENSDARG00000015554 (2)
GENE EXPRESSION
All Expression Data: 36 figures from 20 publications
Directly Submitted Expression Data: 6 figures (19 images) from Thisse et al., 2001 [cb851]
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mn0133Gt Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-zic2a N/A 5
    MO2-zic2a N/A 6
    MO3-zic2a N/A 6
    DISEASE ASSOCIATED WITH zic2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    holoprosencephaly 5 Alliance Holoprosencephaly 5 609637
    DISEASE ASSOCIATED WITH zic2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process diencephalon development (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA zic2a-201 (1)    Ensembl 3177
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM zic2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(11xUAS:zic2a-YFP,myl7:mCherry) myl7UAS mCherryYFPzic2a Danio rerio 1 3
    Tg(zic2a:NLS-Eco.BirA-Hsa.HRAS-mCherry) zic2a mCherryNLS Danio rerioEscherichia coli 1 2
    TgBAC(zic2a:GFP) zic2a GFP Danio rerio 1 7
    MARKER RELATIONSHIPS
    zic2a Contained in: [BAC] CH211-277G23 (1)
    zic2a Encodes: [EST] cb851 (1), fb26a03
    [cDNA] MGC:76802 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131558 (1) 3132 nt
    Genomic GenBank:BX469902 (1) 179135 nt
    Select Tool
    Polypeptide UniProtKB:Q9IAT0 (1) 445 aa
    Sequence Information (all 13)
    ORTHOLOGY for zic2a ( Chr: 9 )
    CITATIONS (53)