ZFIN ID: ZDB-GENE-000427-7
Gene Name: T-box transcription factor 20
Gene Symbol: tbx20    Nomenclature History

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Previous Names: ZF-TBX20 (1), cb826 (1), hrt, hrT (1), whz

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; cloaca development; and regulation of cardiac muscle cell proliferation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in atrial heart septal defect 4. Is expressed in cardiovascular system; digestive system; mesoderm; nervous system; and trunk. Orthologous to human TBX20 (T-box transcription factor 20).
Genome Resources: Alliance (1),  Gene:57936 (1),  Ensembl(GRCz11):ENSDARG00000005150 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hmr1 Small Deletion Unknown Frameshift, Premature Stop CRISPR
la1110 Point Mutation Unknown Premature Stop ENU
m245 Point Mutation Unknown Stop Loss ENU
sa42797 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tpl122 Small Deletion Unknown Unknown CRISPR
    tpl135Tg Transgenic Insertion Intron 2 Unknown DNA_AND_CRISPR
    tpl136Tg Transgenic Insertion Intron 2 Unknown DNA_AND_CRISPR
    tpl145Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tbx20 1
    CRISPR2-tbx20 1
    CRISPR3-tbx20 1
    MO1-tbx20 N/A 4
    MO2-tbx20 N/A 2
    MO3-tbx20 N/A 1
    MO4-tbx20 N/A 1
    MO5-tbx20 N/A 1
    DISEASE ASSOCIATED WITH tbx20 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    atrial heart septal defect 4 Alliance Atrial septal defect 4 611363
    DISEASE ASSOCIATED WITH tbx20 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018186 Transcription factor, T-box, conserved site
    Family IPR001699 Transcription factor, T-box
    Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
    Homologous_superfamily IPR036960 T-box superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbx20-201 (1)    Ensembl 2126
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tbx20 polyclonal IgG Rabbit WB Abcam plc
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbx20
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:GAL4,UAS:tbx20,mCherry) hsp70lUAS GAL4mCherrytbx20 Danio rerio 1 1
    TgBAC(tbx20:GAL4-VP16,myl7:mCherry) myl7tbx20 GAL4mCherryVP16 Danio rerio 1 1
    MARKER RELATIONSHIPS
    tbx20 Contained in: [BAC] CH211-215K15 (1)
    tbx20 Encodes: [EST] cb826 (1) (order this)
    [cDNA] MGC:194995 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131506 (1) 2134 nt
    Genomic GenBank:CR391962 (1) 144859 nt
    Select Tool
    Polypeptide UniProtKB:B3DJG4 (1) 446 aa
    Sequence Information (all 18)
    ORTHOLOGY for tbx20 ( Chr: 16 )
    CITATIONS (106)