ZFIN ID: ZDB-GENE-000329-1
Gene Name: actin, beta 1
Gene Symbol: actb1    Nomenclature History

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Previous Names: bact, actine (1), B-ACTZF, bactin1 (1), wu:fd18f05 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to localize to several cellular components, including actin filament; dense body; and focal adhesion. Is expressed in several structures, including eye; hematopoietic cell; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20. Orthologous to several human genes including ACTB (actin beta).
Genome Resources: Alliance (1),  Gene:57934 (1),  Ensembl(GRCz11):ENSDARG00000037746 (1)
GENE EXPRESSION
All Expression Data: 34 figures from 31 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55989]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013756Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la013757Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la013758Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028200Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH actb1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Baraitser-Winter syndrome Alliance Baraitser-Winter syndrome 1 243310
    ?Dystonia, juvenile-onset 607371
    DISEASE ASSOCIATED WITH actb1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component actin cytoskeleton (more)
    Molecular Function ATP binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA actb1-201 (1)    Ensembl 1788
    actb1-202 (1)    Ensembl 1019
    actb1-204 (1)    Ensembl 796
    actb1-205 (1)    Ensembl 924
    ncRNA actb1-003 (1)    Ensembl 769
    actb1-006 (1)    Ensembl 856
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-actb1 polyclonal Rabbit IHC, WB AnaSpec
    3
    CONSTRUCTS WITH SEQUENCES FROM actb1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.2actb1:gh1,-2.2actb1:GFP) actb1 GFPgh1 Danio rerio 1 2
    Tg(-2.2actb1:smtla,-2.2actb1:GFP) actb1 GFPsmtla Danio rerio 1 2
    Tg(-2.2actb1:smtlb,-2.2actb1:GFP) actb1 GFPsmtlb Danio rerio 1 2
    tg(-2.5actb1:teta-atf4a-2a-mcherry) actb1 2Aatf4amCherryTETA Danio rerio 2 1
    Tg(-2.7actb1:EGFP) actb1 EGFP Danio rerio 1 2
    Tg(actb1:Bta.Ltf-GFP) actb1 GFP Bos taurusDanio rerio 6 4
    Tg(actb1:EGFP) actb1 EGFP Danio rerio 1 3
    Tg(actb1:EGFP-Hsa.HRAS) actb1 EGFP Danio rerioHomo sapiens 1 2
    Tg(actb1:hist2h2l-mCherry) actb1 hist2h2lmCherry Danio rerio 1 3
    Tg(actb1:Hsa.GLRX-roGFP) actb1 roGFP Danio rerioHomo sapiens 1 3
    Tg(actb1:LOXP-mCherry-LOXP-Hsa.TWIST2) actb1 LOXPmCherry Danio rerioHomo sapiens 1 1
    Tg(actb1:LOXP-mCherry-LOXP-Hsa.TWIST2_E75K) actb1 LOXPmCherry Danio rerioHomo sapiens 1 1
    Tg(actb1:LOXP-mCherry-LOXP-Hsa.TWIST2_E75Q) actb1 LOXPmCherry Danio rerioHomo sapiens 1 1
    tg(actb1:loxp-rfp-loxp-gfp) actb1 GFPLOXPRFP Danio rerio 1 1
    Tg(actb1:mCherry-bsmir7a) actb1 mCherry Danio rerio 1 1
    tg(actb1:mneongreen-rac1a) actb1 mNeonGreenrac1a Danio rerio 1 1
    Tg(actb1:NLS-TagRFP) actb1 NLSTagRFP Danio rerio 1 1
    Tg(actb1:sb11,myl7:GFP) actb1myl7 GFP Danio rerio 2 2
    Tg(actb1:Spy.Cas9-UTRactb1) actb1 actb1UTR Danio rerio 1 1
    Tg(gata1a:mir30e-2-shRNAEGFP-actb1-DsRed) gata1a actb1DsRedEGFPmir30e-2 Danio rerio 6 2
    Tg(kdrl:mCherry-actb1) kdrl actb1mCherry Danio rerio 1 4
    Tg(lmo2:mir30e-actb1-DsRed) lmo2 actb1DsRedmir30e-2 Danio rerio 1 2
    Tg(myo6b:actb1-EGFP) myo6b actb1EGFP Danio rerio 1 16
    Tg(T2OncZ,actb1:RFP) actb1 RFP Danio rerio 2 5
    MARKER RELATIONSHIPS
    actb1 Contained in: [BAC] CH211-160D14 (1)
    actb1 Encodes: [EST] fd18f05 (1)
    [cDNA] MGC:55989 (1), MGC:77623 (1), MGC:192419 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131031 (1) 1700 nt
    Genomic GenBank:AL928650 (1) 178563 nt
    Select Tool
    Polypeptide UniProtKB:B2GS08 (1) 375 aa
    Sequence Information (all 29)
    ORTHOLOGY for actb1 ( Chr: 1 )
    CITATIONS (298)