ZFIN ID: ZDB-GENE-000322-5
Gene Name: myosin, heavy polypeptide 1.1, skeletal muscle
Gene Symbol: myhz1.1    Nomenclature History

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Previous Names: cb20 (1), fmyhc1.1 (1), myhz1, myo2hc1 (1), etID37302.5 (1), fast MyHC (1), fb37e12, sb:cb20 (1), si:ch211-158m24.7, wu:fb26a08 (1), wu:fb26f12 (1), wu:fb37e12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in somite specification. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis and multiple pterygium syndrome. Is expressed in several structures, including adaxial cell; brain; eye; musculature system; and somite. Orthologous to several human genes including MYH1 (myosin heavy chain 1).
Genome Resources: Alliance (1),  Gene:58142 (1), 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa33640 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40478 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH myhz1.1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH myhz1.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process somite specification (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR001609 Myosin head, motor domain
    Domain IPR002928 Myosin tail
    Domain IPR004009 Myosin, N-terminal, SH3-like
    Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
    Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myhz1.1-201 (1)    Ensembl 6006
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myhz1.1 No data available
    MARKER RELATIONSHIPS
    myhz1.1 Contained in: [BAC] CH211-158M24 (1)
    myhz1.1 Encodes: [EST] cb20 (1) (order this), fb26a08 (1), fb26f12 (1), fb37e12 (order this)
    [cDNA] MGC:195058 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001115089 (1) 6008 bp
    Genomic GenBank:BX510649 (1) 189844 bp
    Select Tool
    Polypeptide UniProtKB:B3DJM6 (1) 1937 aa
    Sequence Information (all 25)
    ORTHOLOGY for myhz1.1 ( Chr: 5 )
    CITATIONS (49)