ZFIN ID: ZDB-GENE-000322-5
Gene Name: myosin, heavy polypeptide 1.1, skeletal muscle
Gene Symbol: myhz1.1    Nomenclature History

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Previous Names: cb20 (1), fmyhc1.1 (1), myhz1, myo2hc1 (1), etID37302.5 (1), fast MyHC (1), fb37e12, sb:cb20 (1), si:ch211-158m24.7, wu:fb26a08 (1), wu:fb26f12 (1), wu:fb37e12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in somite specification. Predicted to localize to myosin complex. Is expressed in several structures, including adaxial cell; brain; eye; musculature system; and somite. Human ortholog(s) of this gene implicated in disease of cellular proliferation; distal arthrogryposis type 2A; distal arthrogryposis type 2B1; distal arthrogryposis type 2B3; and distal arthrogryposis type 7. Orthologous to several human genes including MYH1 (myosin heavy chain 1) and MYH8 (myosin heavy chain 8).
Genome Resources: Alliance (1),  Gene:58142 (1), 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa33640 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40478 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH myhz1.1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    inclusion body myositis Alliance Proximal myopathy and ophthalmoplegia 605637
    DISEASE ASSOCIATED WITH myhz1.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process somite specification (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myhz1.1-201 (1)    Ensembl 6006
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myhz1.1 No data available
    MARKER RELATIONSHIPS
    myhz1.1 Contained in: [BAC] CH211-158M24 (1)
    myhz1.1 Encodes: [EST] cb20 (1) (order this), fb26a08 (1), fb26f12 (1), fb37e12 (order this)
    [cDNA] MGC:195058 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001115089 (1) 6008 nt
    Genomic GenBank:BX510649 (1) 189844 nt
    Select Tool
    Polypeptide UniProtKB:B3DJM6 (1) 1937 aa
    Sequence Information (all 25)
    ORTHOLOGY for myhz1.1 ( Chr: 5 )
    CITATIONS (50)