ZFIN ID: ZDB-GENE-000210-20
Gene Name: catalase
Gene Symbol: cat    Nomenclature History

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Previous Names: fb68a12, wu:fb68a12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have catalase activity and heme binding activity. Involved in response to copper ion. Predicted to localize to mitochondrion and peroxisome. Is expressed in digestive system; gill; head; muscle; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase).
Genome Resources: Alliance (1),  Gene:30068 (1),  Ensembl(GRCz11):ENSDARG00000104702 (1)
GENE EXPRESSION
All Expression Data: 23 figures from 15 publications
Directly Submitted Expression Data: 7 figures (5 images) from Thisse et al., 2004 [MGC:56675]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ic3036 Small Deletion Unknown Frameshift, Premature Stop CRISPR
sa13124 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16024 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31106 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38000 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cat 1
    CRISPR2-cat 1
    MO1-cat N/A 1
    DISEASE ASSOCIATED WITH cat HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acatalasia Alliance Acatalasemia 614097
    DISEASE ASSOCIATED WITH cat VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to copper ion (more)
    Cellular Component peroxisome (more)
    Molecular Function catalase activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cat-201 (1)    Ensembl 2054
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-cat polyclonal Rabbit Sigma-Aldrich
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cat
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(ins:cat,ins:hsa.hist1h2bj-mcherry,cryaa:yfp) cryaains catmCherryYFP Danio rerioHomo sapiens 1 1
    tg(krtt1c19e:cat,myl7:mcherry) krtt1c19emyl7 catmCherry Danio rerio 1 1
    Tg(myl7:cat-DsRed) myl7 catDsRed Danio rerio 1 2
    MARKER RELATIONSHIPS
    cat Contained in: [Fosmid] CH1073-463L14 (1)
    cat Encodes: [EST] fb68a12 (1)
    [cDNA] MGC:56675 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130912 (1) 2260 nt
    Genomic GenBank:CU694456 (1) 25610 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4II89 (1) 526 aa
    Sequence Information (all 27)
    ORTHOLOGY for cat ( Chr: 25 )
    CITATIONS (242)