FIGURE

Fig. 3

ID

ZDB-FIG-240725-30

Publication

Li et al., 2024 - Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury

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Fig. 3

The function of mitochondria was impaired in the elovl2−/− hepatocyte. A, mitochondria ultrastructure in the hepatocytes of WT and −/−. m: mitochondria. Scale bar: 200 nm. B and C, flow cytometric analysis of mitochondrial transmembrane potential after staining with JC-1 and statistical analysis of the PE/FITC fluorescence ratios. D, analysis of ATP production in WT and −/− livers. E, heatmap of genes related with multiheteromeric enzyme complexes of oxidative phosphorylation in WT and −/− livers. F–I, qRT-PCR analysis of genes related with multiheteromeric enzyme complexes of oxidative phosphorylation in WT and −/− livers. N = 3 replicates. All values are mean ± SD. A Student t test was used. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. Individual p values are listed in Table S5 . −/−, elovl2−/−; WT, wildtype.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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