FIGURE

Fig. 3

ID

ZDB-FIG-240708-42

Publication

McKaige et al., 2024 - Mitochondrial abnormalities contribute to muscle weakness in a Dnajb6 deficient zebrafish model

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Fig. 3

Functional analysis reveals late onset muscle weakness in double dnajb6 mutants. (A) The distance travelled was not significantly different between genotypes at 6 dpf. The swimming of dnajb6 fish was recorded for a period of 10 min and each dot represents an individual fish. Analysis was completed in triplicate with n ≥ 38 per genotype. Error bars show standard error of the mean (SEM). Genotypes were compared using a linear model. (B) Double mutant fish show a significant decline in motor function over time (P = 0.007). Fish were genotyped prior to the start of the experiment and their movement was recorded weekly from 2 weeks post fertilisation (wpf) to 12 wpf. Each dot represents the average swimming distance of one group, with six groups per genotype. Analysis was completed with n ≥ 34 per genotype from week 2 onwards and a mixed linear model. (C) Survival of double mutant fish was significantly less than wildtype fish (P = 0.0005). Analysis was completed with n ≥ 29 per genotype from week 1 onwards. Kaplan–Meier survival curves were compared using the mantel-cox log rank test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.