FIGURE

Fig. 7

ID

ZDB-FIG-230710-49

Publication

Hadzhiev et al., 2023 - The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation

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Fig. 7

Models of minor wave gene activation in and outside of the miR-430 transcription body

(A) The miR-430 cluster on chr4 with high promoter density forms a microenvironment during the minor wave of ZGA. Minor wave gene activation occurs distal to the transcription body, such as at the gata3 and klf17 loci, which share promoter architecture features with miR-430 gene but are activated independently from the transcription body (top). Genes that have distinct promoter features from minor wave genes are not activated until the major wave of ZGA (bottom), while minor wave genes continue to function during the major wave of ZGA.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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Reprinted from Developmental Cell, 58, Hadzhiev, Y., Wheatley, L., Cooper, L., Ansaloni, F., Whalley, C., Chen, Z., Finaurini, S., Gustincich, S., Sanges, R., Burgess, S., Beggs, A., Müller, F., The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation, 155170.e8155-170.e8, Copyright (2023) with permission from Elsevier. Full text @ Dev. Cell