FIGURE

Figure 4

ID

ZDB-FIG-230613-58

Publication

Stępnik et al., 2023 - Significance of Astragaloside IV from the Roots of Astragalus mongholicus as an Acetylcholinesterase Inhibitor-From the Computational and Biomimetic Analyses to the In Vitro and In Vivo Studies of Safety

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Figure 4

(A) Correlation between the logP_ow values (taken from [32]) and the smallest value of the free energy profiles associated with the permeability of the studied compounds through the lipid bilayer. The lipid bilayer was composed of either POPC molecules (red points) or POPG molecules (green points). The error bars correspond to the combined bootstrapping errors determined for the smallest value of the energy and the value for the molecule located outside the bilayer. (B) The same as in (A) but the correlation calculated for the logPS_Fubrain values. (C) Correlation between experimentally-determined IC₅₀ values (recalculated as log(IC₅₀)) and the theoretical ligand-AChE binding energies.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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