Figure 3.
- ID
- ZDB-FIG-230513-38
- Publication
- Goh et al., 2023 - Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish
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MBC and MIC determination of the combination of clarithromycin (Clr) and rifaximin (Rfx) on M. abscessus ATCC 19977. The cfu counts were determined for the cells treated with 0.5×, 1×, 2×, 4× and 8 × MIC of clarithromycin in the presence of 1 × MIC of rifaximin, and vice versa. The MBC90 (orange line) was defined as the lowest drug concentration required to induce >90% cell death compared with the starting inoculum (at 0 h timepoint) of the untreated control. The number of residual log10 cfu/mL was determined through plating 10-fold serial dilution and compared with the starting inoculum. Statistical significance was determined by a two-tailed Student’s t-test with Welch’s correction; *P < 0.05; **P < 0.01. The dashed black line indicates the limit of detection. The experiments were carried out in duplicates; error bars represent the SD. |