Fig. 8
- ID
- ZDB-FIG-230327-51
- Publication
- Wang et al., 2022 - Discovery of anti-stroke active substances in Guhong injection based on multi-phenotypic screening of zebrafish
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Fig. 8. RT-qPCR combined with molecular docking revealing anti-inflammatory effects of GHI and its active compounds targeting NF-κB pathway. (A-H) The relative mRNA expression levels of NF-κB (A, E), TNF-α (B, F), IL-6 (C, G), and IL-1β (D, H) in PHZ-stimulated (A-D) and PON-stimualted (E-H) zebrafish embryos. (I-L) Molecular docking results of baicalein (I), chlorogenic acid (J), gallic acid (K), and rutin (L) targeting NF-κB p65. Data are shown as the mean ± SD. #p < 0.05, and ##p < 0.01 versus the control group; *p < 0.05, and **p < 0.01 versus the PHZ group or PON group. PHZ, phenylhydrazine; PON, ponatinib; GHI, Guhong injection. |