FIGURE
Figure 1
- ID
- ZDB-FIG-230123-13
- Publication
- Sabharwal et al., 2022 - Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality
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Figure 1
GBT mutagenesis generates a novel zebrafish model of LSFC.(A) Schematic of human and zebrafish LRPPRC proteins with highlighted PPR domains (denoted by P). (B) Schematic of the integration event of GBT vector RP2.1 with 5’ protein trap and 3’ exon trap cassettes. The RP2.1 cassette was integrated into the intronic region 22 of the lrpprc genomic locus on chromosome 13. ITR, inverted terminal repeat; SA, loxP; Cre recombinase recognition sequence, splice acceptor; *mRFP’ AUG-less mRFP sequence; poly (A) +, polyadenylation signal; red-octagon, extra transcriptional terminator and putative border element; β-act, carp beta-actin enhancer, SD, splice donor. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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