FIGURE

Fig. 5

ID

ZDB-FIG-221226-328

Publication

Vettkötter et al., 2022 - Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles

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Fig. 5

zf-optoSynC activation in zebrafish neurons blocks escape behavior.

a, b Pan-neuronal expression of eGFP in neurons of zebrafish larvae at the indicated developmental stages. Representative images show transient expression in Tg(elavl3.2:Gal4-VP16)mde4 animals injected with UAS:zf-optoSynC (n = 2 independent experiments). c Swimming behavior, triggered by continuous blue light (blue bar), in 4 dpf larvae expressing the respective transgene, as indicated. Mean ± s.e.m., numbers of individual animals are indicated. d Statistical analysis of data in c, as median and 75–25% IQR. Number of independent animals n = 7 (eGFP) and n = 6 (zf-optoSynC). e Touch response of 3 dpf larvae during blue light-induced zf-optoSynC/CRY2olig(535) clustering. Two experiments, number of animals is indicated. Unpaired Student’s t test (two-tailed) in d, and Fisher’s exact test (two-sided) in e.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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