FIGURE

Figure 5.

ID

ZDB-FIG-220414-13

Publication

Tallafuss et al., 2022 - Egr1 is necessary for forebrain dopaminergic signaling during social behavior

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Figure 5.

Egr1 is necessary for TH-positive neuron number in BF. A–A’’, Dorsal view of maximum projection of the BF region (magenta box in E) of Et ^y321 larval zebrafish at 14 dpf labeled with antibodies to GFP (green) and TH (magenta). Anterior commissure (AC); anterior is to the top. B–D, Maximum projections of TH labeling in the BF region posterior to the AC for egr1 wt (B), hets (C) and mutants (D). Scale bars: 30 μm. E, Diagrammatic side-view of the larval brain highlighting the regions (magenta and cyan) analyzed as a maximum projection Z-stacks in A, B–D, respectively. F, Quantification of the number of TH-positive neurons in the cyan region in E revealed a decrease in egr1 mutants at 14 dpf. N = 2 experiments, n = 18 brains, p < 0.05 (HSD). G, The same quantification as in F at 7 dpf demonstrates a consistent decrease in TH-positive neurons during development. N = 2, n = 24, p < 0.05 (HSD). wt (+/+, white), het (+/−, light gray), mut (−/−, dark gray). Error bars are SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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