FIGURE

Fig 5

ID
ZDB-FIG-211116-14
Publication
Bühler et al., 2021 - Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish
Other Figures
All Figure Page
Back to All Figure Page
Fig 5

Hdac1 mRNA injection rescues the bal phenotype.

(A-E) Lateral view of uninjected and hdac1 mRNA injected wildtyp (A, C) or bal embryos (B, D) at 72 hpf, injection of mRNA prevents the bal phenotype in mutant embryos (uninjected 0 ± 0%, hdac1 mRNA injected 47.4 ± 14.76%, n = 50 embryos). (F-I) Cardiomyocytes (red) in Tg(myl7:mCherry), bal;Tg(myl7:mCherry) and hdac1 mRNA injected bal;Tg(myl7:mCherry) hearts. Hdac1 mRNA injection prevents the loss of ventricular cardiomyocytes in bal mutant embryos. (J-N) Statistical analysis of pH3+ cardiomyocytes after hdac1 mRNA injection in bal;Tg(myl7:mCherry) mutant embyos (wt: 4.2 ± 1.40; bal: 0.9 ± 0.88; bal + hdac1 mRNA: 2.9 ± 1.37, n = 10) and the relative proliferation rate (wt: 2.19 ± 0.66%; bal: 0.70 ± 0.68%; bal + hdac1 mRNA: 1.48 ± 0.69%, n = 10). Error bars indicate s.d.; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns, not significant.

Expression Data
Gene:
Fish:
Anatomical Term:
Stage: Protruding-mouth

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Protruding-mouth

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.