FIGURE

FIGURE 6

ID

ZDB-FIG-210518-17

Publication

Cheng et al., 2021 - Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations

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FIGURE 6

(A) Lys48-ubiquitylation E3 ligase activity assay of immunoprecipitated cyclin F from cells expressing cyclin F wild-type, K97R, S195R, S509P, R574Q, and S621G. (B) Cyclin F interacts with caspase 3. HEK293 cells transfected with mCherry-cyclin F and immunoprecipitated (left blot) shows interaction with endogenous caspase-3. The reverse immunoprecipitation to enrich caspase-3 showed the same interaction with cyclin F (right blot).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.