FIGURE
Figure 6
- ID
- ZDB-FIG-210503-95
- Publication
- Ko et al., 2021 - Differential Regulation of Ca2+-Activated Cl- Channel TMEM16A Splice Variants by Membrane PI(4,5)P2
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Figure 6
Modulation of TMEM16A(ac) channels by the M1 muscarinic receptor (M1R). (A) Representative Cl− current traces of TMEM16A(ac) before and after application of the M1R agonist oxotremorine-M (Oxo-M). Whole-cell recordings were measured before (t0, black) and 200 s after (t200, gray and red) the application of 10 μM Oxo-M in cells co-transfected without (left) and with (right) M1R. Cells were dialyzed with an intracellular solution including 10 mM EGTA and zero Ca2+, and the current was measured at +100 mV every 5 s. (B) Normalized mean current ± SEM. TMEM16A(ac), n = 5; TMEM16A(ac) + M1R, n = 5. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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