FIGURE

Figure 1

ID

ZDB-FIG-210413-2

Publication

Ivica et al., 2021 - The intracellular domain of homomeric glycine receptors modulates agonist efficacy

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

GlyR agonist efficacy is lower in humanα1 GlyR than in zebrafishα1 GlyR_EM, a channel from which the ICD has been excised.A and B, upper panels, whole cell current responses to the application of glycine, β-alanine, taurine, and GABA by U-tube to HEK 293 cells expressing human α1 GlyR (A) or zebrafish α1 GlyR_EM (B). A and B, lower panels, averaged concentration-response curves of glycine (black), β-alanine (blue), taurine (red), and GABA (green) in human α1 GlyR (A) and zebrafish α1 GlyR_EM (B). Each dose-response curve is constructed by pooling individual concentration-response curves obtained in different cells (n = 4 –14, see Table 1). Error bars represent S.E. Responses were normalized to the response to 10 mm glycine in each cell.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.