FIGURE

Figure 8

ID

ZDB-FIG-210204-72

Publication

Bai et al., 2021 - Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor-Deficient Zebrafish

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Figure 8

Summary of the experimental workflow and findings. Global metabolomics and lipidomics analysis were performed to study the metabolic change of gcgr^−/− mutant zebrafish. One hundred seven significantly different metabolites were found by metabolomics, and most of these metabolites were lipid and lipid-like molecules. Eighty-seven significantly different lipids were found by lipidomics. Integration analyses of metabolomics, lipidomics, and transcriptomics were then performed. Based on the analysis, we found that gcgr^−/− zebrafish displayed some similar metabolic changes to other studies. Importantly, we found that knockout of GCGR in zebrafish resulted in down-regulated tryptophan metabolism, up-regulated arachidonic acid metabolism, and disruption of glycerophospholipid metabolism.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol