ZFIN ID: ZDB-FIG-200713-36
Peron et al., 2020 - The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent. Development (Cambridge, England)   147(12) Full text @ Development
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Days 7-13 to Days 30-44

Fig. 6.

Stat3 is required for intestinal homeostasis and larvae survival during development. (A) Percentage of the different genotypes found at different time points in stat3+/− incross; stat3−/− mutants were never found after 25 dpf, with the exception of a single animal that died at 51 dpf (shown in B). Statistical analysis was performed by chi-square test to compare proportions. (B) Haematoxylin-eosin staining of longitudinal sections at different larval stages (indicated on the left); arrowhead indicates the intestinal epithelium. Compared with normal fish, mutants display flattening of the intestinal epithelium. (C) Percentage of individuals at different stages presenting either normal intestine or degenerated intestine lacking intestinal folds. *P<0.05; **P<0.01.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
stat3ia23/ia23 standard conditions Days 7-13 intestinal epithelium lacks parts or has fewer parts of type intervillus pockets, abnormal
Days 7-13 - Days 21-29 whole organism viability, abnormal
Days 14-20 intestinal epithelium lacks parts or has fewer parts of type intervillus pockets, abnormal
Days 21-29 intestinal epithelium lacks parts or has fewer parts of type intervillus pockets, abnormal
Days 30-44 whole organism dead, abnormal
Acknowledgments:
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