ZFIN ID: ZDB-FIG-200416-15
Thyme et al., 2019 - Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell   177(2):478-491.e20 Full text @ Cell
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 4

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
akt3ba230/a230 standard conditions Day 4 habituation decreased rate, abnormal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light increased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming increased linear velocity, abnormal
Day 4 swimming increased spatial extent of a process, abnormal
Day 4 swimming normal occurrence, normal
ambra1aa223/a223 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light decreased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming increased linear velocity, abnormal
Day 4 swimming increased spatial extent of a process, abnormal
Day 4 swimming normal occurrence, normal
arhgap1a232/a232 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light increased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming increased linear velocity, abnormal
Day 4 swimming increased occurrence, abnormal
Day 4 swimming increased spatial extent of a process, abnormal
astn1a235/a235 standard conditions Day 4 habituation increased rate, abnormal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light decreased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
Day 4 swimming normal frequency, normal
Day 4 swimming normal occurrence, normal
atxn7a236/a236 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light increased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
Day 4 swimming increased frequency, abnormal
Day 4 swimming normal occurrence, normal
brinp2a222/a222 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition decreased magnitude, abnormal
Day 4 response to absence of light decreased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response magnitude, normal
Day 4 swimming normal frequency, normal
Day 4 swimming normal occurrence, normal
cacna1ca366/a366 standard conditions Day 4 habituation decreased rate, abnormal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light increased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased occurrence, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
chrm4aa248/a248 standard conditions Day 4 habituation decreased rate, abnormal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light decreased process quality, abnormal
Day 4 response to light stimulus decreased process quality, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
Day 4 swimming increased frequency, abnormal
Day 4 swimming increased occurrence, abnormal
clcn3a251/a251 standard conditions Day 4 habituation decreased rate, abnormal
Day 4 prepulse inhibition decreased magnitude, abnormal
Day 4 response to absence of light increased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response increased magnitude, abnormal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming decreased occurrence, abnormal
Day 4 swimming increased linear velocity, abnormal
Day 4 swimming increased spatial extent of a process, abnormal
cnnm2ba258/a258 standard conditions Day 4 habituation increased rate, abnormal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light decreased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
Day 4 swimming increased frequency, abnormal
Day 4 swimming increased occurrence, abnormal
csmd3aa254/a254 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming increased linear velocity, abnormal
Day 4 swimming increased spatial extent of a process, abnormal
Day 4 swimming normal occurrence, normal
egr1a264/a264 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition decreased magnitude, abnormal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
Day 4 swimming normal occurrence, normal
fpgta268/a268 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition decreased magnitude, abnormal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response increased magnitude, abnormal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming increased linear velocity, abnormal
Day 4 swimming increased spatial extent of a process, abnormal
Day 4 swimming normal occurrence, normal
gigyf2a273/a273 standard conditions Day 4 habituation decreased rate, abnormal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light increased process quality, abnormal
Day 4 response to light stimulus decreased process quality, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
Day 4 swimming increased frequency, abnormal
Day 4 swimming normal occurrence, normal
gramd1baa278/a278 standard conditions Day 4 habituation increased rate, abnormal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light increased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
Day 4 swimming increased frequency, abnormal
Day 4 swimming normal occurrence, normal
hcn1a283/a283 standard conditions Day 4 habituation increased rate, abnormal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming decreased occurrence, abnormal
Day 4 swimming increased linear velocity, abnormal
Day 4 swimming increased spatial extent of a process, abnormal
ireb2a287/a287 standard conditions Day 4 habituation decreased rate, abnormal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
Day 4 swimming increased frequency, abnormal
Day 4 swimming normal occurrence, normal
kmt2ea226/a226 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light increased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased occurrence, abnormal
Day 4 swimming increased frequency, abnormal
Day 4 swimming increased linear velocity, abnormal
Day 4 swimming increased spatial extent of a process, abnormal
luzp2a353/a353 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light increased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 swimming normal frequency, normal
Day 4 swimming normal occurrence, normal
man2a2a298/a298 standard conditions Day 4 habituation increased rate, abnormal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased occurrence, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
mir137-1a368/a368 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming increased linear velocity, abnormal
Day 4 swimming increased spatial extent of a process, abnormal
Day 4 swimming normal occurrence, normal
ntma308/a308 standard conditions Day 4 habituation decreased rate, abnormal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light decreased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming increased frequency, abnormal
Day 4 swimming normal occurrence, normal
rgs6a318/a318 standard conditions Day 4 habituation increased rate, abnormal
Day 4 prepulse inhibition decreased magnitude, abnormal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming normal occurrence, normal
sbno1a214/a214 standard conditions Day 4 habituation decreased rate, abnormal
Day 4 prepulse inhibition increased magnitude, abnormal
Day 4 response to absence of light decreased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response decreased magnitude, abnormal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased occurrence, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
snap91aa337/a337 standard conditions Day 4 habituation increased rate, abnormal
Day 4 prepulse inhibition decreased magnitude, abnormal
Day 4 response to absence of light decreased process quality, abnormal
Day 4 response to light stimulus increased process quality, abnormal
Day 4 swimming decreased linear velocity, abnormal
Day 4 swimming decreased occurrence, abnormal
Day 4 swimming decreased spatial extent of a process, abnormal
Day 4 swimming increased frequency, abnormal
tsnare1a362/a362 standard conditions Day 4 habituation increased rate, abnormal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 startle response increased magnitude, abnormal
Day 4 swimming normal frequency, normal
Day 4 swimming normal occurrence, normal
vrk2a363/a363 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition decreased magnitude, abnormal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 swimming decreased frequency, abnormal
Day 4 swimming increased linear velocity, abnormal
Day 4 swimming increased spatial extent of a process, abnormal
Day 4 swimming normal occurrence, normal
zgc:153521a373/a373 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light decreased process quality, abnormal
Day 4 response to light stimulus normal process quality, normal
Day 4 swimming normal frequency, normal
Day 4 swimming normal occurrence, normal
znf536a211/a211 standard conditions Day 4 habituation normal rate, normal
Day 4 prepulse inhibition magnitude, normal
Day 4 response to absence of light normal process quality, normal
Day 4 response to light stimulus normal process quality, normal
Day 4 swimming increased occurrence, abnormal
Day 4 swimming normal frequency, normal
Acknowledgments:
ZFIN wishes to thank the journal Cell for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Cell, 177(2), Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F., Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions, 478-491.e20, Copyright (2019) with permission from Elsevier. Full text @ Cell