FIGURE

Fig. 2

ID

ZDB-FIG-190626-49

Publication

Chopra et al., 2019 - Zebrafish duox mutations provide a model for human congenital hypothyroidism

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Fig. 2

duox mutants exhibit growth retardation. Mutants for both alleles as well as compound heterozygotes are shorter than their WT and heterozygous siblings at 3 months (A–G) but catch up by 6 months (H). sa13017^−/− animals are trailing behind even at 6 months (H). Asterisks in G denote statistically significant differences (Bonferroni's multiple comparisons test, ****P<0.0001) duox mutants also have a delay in the inflation of the anterior lobe of the swim bladder (I,J) (white arrowheads indicate lobes). Adults at 3 months old also lack barbels (L–P), which are observed in heterozygous siblings (white arrowheads; K,N). Barbels emerge in some older animals (6 months and older) (white arrowhead, M). External goitres are often visible in young adults (black arrowheads; L,O). Scale bars: 1 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	duox^{sa9892/sa9892} duox^{sa13017/sa13017} duox^sa9892/+ duox^sa13017/+ duox^sa13017/+; duox^sa9892/+ duox^{sa9892/sa9892}; mitfa^w2/w2
Observed In:	anterior chamber swim bladder barbel head thyroid follicle whole organism
Stage Range:	Days 45-89 to Adult

Phenotype Detail

Acknowledgments

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