ZFIN ID: ZDB-FIG-190618-6
Young et al., 2019 - Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification. eLIFE   8 Full text @ Elife
Anatomical Term:
Stage: Prim-25
Observed In:
Stage: Prim-25

Fig. 6

Ztcf7l1a mutants show more retinal progenitor cells undergoing proliferation.

(A–B) Immunostaining detecting phosphohistone3 (PH3, green) and RFP (Tg(atoh7:GAP-RFP)cu2Tg-, red) in wildtype (A) and Ztcf7l1a-/- (B) eyes at 36hpf . Arrows indicate selected double PH3/RFP positive cells. n, nasal; t, temporal. Scale bar = 100 µm. (C–D) Plot showing the percentage of PH3-positive cells (C) data in Supplementary file 1L) and double PH3/RFP-positive cells (D), data in Supplementary file 1L). Single experiment, wildtype n = 7, Ztcf7l1a-/-n = 8, figures over the bars show p-values from unpaired t-tests.


Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
RFP cu2Tg standard conditions Prim-25 retina neuron IHC
cu2Tg ; tcf7l1am881/m881 standard conditions Prim-25 retina neuron IHC
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
cu2Tg ; tcf7l1am881/m881 standard conditions Prim-25 retina neuron RFP expression decreased amount, abnormal
ZFIN wishes to thank the journal eLIFE for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Elife