FIGURE

Fig. 4

ID

ZDB-FIG-190530-32

Publication

DuVal et al., 2018 - Photoreceptor Progenitors Depend Upon Coordination of gdf6a, thrβ, and tbx2b to Generate Precise Populations of Cone Photoreceptor Subtypes

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Thrβ disruption with dnThrβ does not rescue the gdf6^s327/s327 blue cone phenotype. (A) Expression of dominant negative thrβ (dnthrβ) increases UV and blue cone abundances, but in gdf6a^s327^s327 mutants (labeled gdf6a^−/− or “−/−”) the low blue cone abundance is not changed and UV cones are not increased with dnthrβ expression. Gdf6a^s327^s327 mutants have reduced red cone abundance regardless of dnthrβ expression compared to nontransgenic wildtype siblings. Values with matching letters are not significantly different (Kruskal-Wallis test with Mann-Whitney pairwise comparisons, gray asterisks indicate *P < 0.05, **P < 0.01, ***P < 0.001 relative to WT sibling HS control). (B) Representative retinal images of wild-type sibling gdf6a^s327^s327 and gdf6a^s327^s327 with dnthrβ expression.

Expression Data

Antibodies:	Ab1-10C9.1 Ab3-rho
Fish:	WT gdf6a^s327/s327 kj9Tg; ua3011Tg; ua3113Tg gdf6a^s327/s327; kj9Tg; ua3011Tg; ua3113Tg
Condition:	heat shock
Anatomical Terms:	red sensitive photoreceptor cell UV sensitive photoreceptor cell
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gdf6a^s327/s327 kj9Tg; ua3011Tg; ua3113Tg gdf6a^s327/s327; kj9Tg; ua3011Tg; ua3113Tg
Condition:	heat shock
Observed In:	blue sensitive photoreceptor cell red sensitive photoreceptor cell UV sensitive photoreceptor cell
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.