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ZFIN ID: ZDB-FIG-190218-13
Deiana et al., 2018 - New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration. Cells   7(11) Full text @ Cells
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage: Days 7-13

Fig. 9 Differential migratory ability of wild-type and del-RUNT cells in zebrafish xeno-transplants. Representative images show wild-type (WT, stained in red) and del-RUNT (del-RUNT, stained in green) cells xeno-transplanted in zebrafish embryos 2 days post fertilization (dpf). At day 0 post injection (dpi), transplanted cells are still located in the yolk. At 5 dpi, cells appear more dispersed in the yolk of 7 dpf larvae. At 7 dpi/9 dpf, initial metastases (indicated by white arrowheads) are detectable in WT and, to a lesser extent, in del-RUNT- transplanted larvae. All views are lateral, anterior to the left. Charts on average number of metastases and cell spreading, calculated at 9 dpf in WT (N:22) and del-Runt (N:12) transplanted zebrafish, are shown in (A) and (B), respectively. * p < 0.05.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
mitfaw2/w2 cancer xenotransplantation Days 7-13 whole organism melanoma neoplastic, metastatic, abnormal
Days 7-13 whole organism melanoma present, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Cells for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Cells