FIGURE

Fig. 7

ID

ZDB-FIG-190201-26

Publication

Shaw et al., 2018 - Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

C9orf72 model zebrafish display muscle atrophy and motor neuron loss. (a) Representative H&E staining of zebrafish epaxial muscle (body muscle) myotomes. Scale bar = 50 μm. (b) Frequency distribution of 2.2–2 and NTG myotome sizes. N = 6 individual zebrafish per genotype. (c) Motor neuron counts show that 2.2–7 zebrafish have significant motor neuron loss compared to NTG. N = 6 individual fish per genotype. (d) Representative H&E staining of zebrafish spinal cord sections, motor neurons are denoted by arrowheads. Scale bar = 25 μm. Myotome size data are shown as the frequency of myotome sizes binned into defined ranges, motor neuron count data are mean +/− standard deviation; *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sh578Tg sh579Tg
Observed In:	myotome skeletal muscle cell spinal cord motor neuron
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Acta Neuropathol Commun