FIGURE

Fig. 2

ID

ZDB-FIG-190201-25

Publication

Shaw et al., 2018 - Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

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Fig. 2

C9orf72 model zebrafish display DPR expression in the nucleus. (a,b) Immunofluorescence labelling of adult zebrafish muscle tissue showed that poly-GP DPR protein localises to the nucleus in 2.2–2 and 2.2–7 transgenic zebrafish. (c.d) Immunofluorescence labelling of adult zebrafish muscle tissue showed that poly-PA DPR protein localises to the nucleus in 2.2–2 and 2.2–7 transgenic zebrafish. (e,f) Immunofluorescence labelling of adult zebrafish muscle tissue showed that poly-PA DPR protein localises to the nucleus in 2.2–2 and 2.2–7 transgenic zebrafish. For all DPR images nuclei are stained with Hoechst (blue), GFP is stained with GFP antibody (green) and DPR proteins are stained with the relevant DPR antibody (purple), white arrow heads denote DPR positive staining. Scale bar = 25 μm for all DPR images

Expression Data

Gene:	GFP
Fish:	sh578Tg sh579Tg
Anatomical Term:	muscle cell nucleus
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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