FIGURE

Fig. S7

ID

ZDB-FIG-181022-13

Publication

Lawrence et al., 2018 - The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function, which leads to early-onset osteoarthritis.

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Fig. S7

Mutation of col11a2 does not alter muscle fibre number or diameter at 5dpf. A) smyhc:gfp;col2a1:mCherry transgenic line shows slow myosin in muscle (green) and Type II collagen (red) in wt and col11a2-/- zebrafish at 5dpf. B) Quantification of muscle fibre number in four muscles in the jaw in wt and col11a2-/- zebrafish (n = 5 and 8 respectively). C) Quantification of muscle diameter in two muscles in the lower jaw, observed through birefringence in wt and col11a2-/- zebrafish at 5dpf (n=3 for all). Locations of muscles are labelled and shown in (A) (IP = Intermandibularis posterior, IH = interhyoideus, AM = adductor mandibulae, HH = hyohyoideus). Student's unpaired t-tests were performed in B and C, data is mean with SEM. Scale bar = 100 µm. n.s = P>0.05

Expression Data

Genes:	EGFP mCherry
Fish:	hu5910Tg; i104Tg col11a2^{sa18324/sa18324}; hu5910Tg; i104Tg
Anatomical Terms:	adductor mandibulae hyohyoideus interhyoideus pharyngeal arch cartilage ventral intermandibularis posterior
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Phil. Trans. Roy. Soc. Lond., Series B