FIGURE

Fig. 1

ID

ZDB-FIG-180928-6

Publication

Ai et al., 2018 - Ponatinib exerts anti-angiogenic effects in the zebrafish and human umbilical vein endothelial cells via blocking VEGFR signaling pathway

Other Figures

Fig. 1

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Fig. 1

Effects of Ponatinib on vascular development of zebrafish larvae. (A) Fluorescent images of ISV and SIV in the zebrafish embryos incubated with 0.1% DMSO (Ctrl: vehicle-control), VRI (5 ?M), and Ponatinib (1, 3 and 10 ?M) for 48 h. VRI was used as the positive control. Red arrow: normal ISV. (B) Number of normal ISV with full-length formation. (C) Quantification of SIV area as a percentage of the control group. The total SIV area was determined by using the NIH image J program. (D) Formation of selected ISV (NO. 4, 7, and 10). All values are presented as means � SD (n = 12). ^*P < 0.05 vs. control group, and ^***P < 0.005 vs. control group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg
Conditions:	chemical treatment by environment: ponatinib chemical treatment by environment: vascular endothelial growth factor receptor antagonist
Observed In:	angiogenesis intersegmental vessel subintestinal vein
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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