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ZIRC
ZFIN ID: ZDB-FIG-180112-11
Facchinello et al., 2017 - nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor. Scientific Reports   7:4371 Full text @ Sci. Rep.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 2

Histology of 8-month-old gr −/− and gr +/+ zebrafish. All histological images of 8-month-old gr −/− and gr +/+ zebrafish were taken from longitudinal sections stained with haematoxylin and eosin (H&E). The left panels represent wild type fish, whereas the middle and right panels show tissues from two mutant fish. (A) heart; (B) particular of the heart at higher magnification showing reduced trabecular network in the mutant samples; (C) intestinal mucosa with sloughing epithelium at the villous tips and reduced height of villi in mutants; (D) visceral view showing reduced extension of pancreas in mutants; (E) consistent increase of subcutaneous adipose tissue in mutants. ba = bulbus arteriosus; v = ventricle; a = adipose tissue; i = intestine; p = pancreas; t = trabeculae.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
nr3c1ia30/ia30 standard conditions Adult heart structure, abnormal
Adult intestinal bulb epithelium decreased thickness, abnormal
Adult pancreas decreased size, abnormal
Adult subcutaneous fat increased amount, abnormal
Adult trabecular layer of ventricle decreased object quality, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Scientific Reports for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Sci. Rep.