FIGURE

Fig. S14

ID

ZDB-FIG-170110-40

Publication

Xiao et al., 2016 - Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish

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Fig. S14

Dnmt3ab is required for myocardial proliferation. (a) Quantitative PCR showed that dnmt3ab was induced in injured hearts at 3, 7, and 14 dpa compared with sham hearts (**P <0.01; ***P <0.001; data presented are mean ± s.e.m.; paired Student’s t-test). (b) Quantitative PCR showed that nanoparticle-mediated dnmt3ab siRNA decreased the RNA level of dnmt3ab in wild-type hearts (*P <0.05; data presented are mean ± s.e.m.; unpaired Student’s t-test). (c-e) BrdU ⁺/Mef2C⁺ proliferating cardiomyocytes decreased in dnmt3ab siRNA hearts (d) compared with negative control (NC) siRNA heart (c) at 14 dpa. The number (n) of hearts analyzed in each group is indicated in each bar (***P <0.001; data presented are mean ± s.e.m.; paired Student’s t-test). Scale bar, 100μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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