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General Information
ZIRC
ZFIN ID: ZDB-FIG-170110-17
O'Grady et al., 2016 - Variants in the Oxidoreductase PYROXD1 Cause Early-Onset Myopathy with Internalized Nuclei and Myofibrillar Disorganization. American journal of human genetics   99(5):1086-1105 Full text @ Am. J. Hum. Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Antibodies:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage Range: Long-pec to Day 4
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Long-pec to Day 4

Fig. 8 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
pyroxd1 Ab1-ryroxd1 WT standard conditions Long-pec whole organism WB
Ab1-ryroxd1 WT + MO1-pyroxd1 standard conditions Long-pec whole organism WB
Long-pec whole organism RTPCR
Ab1-ryroxd1 WT + MO1-pyroxd1 + MO2-pyroxd1 standard conditions Long-pec whole organism WB
Ab1-ryroxd1 WT + MO2-pyroxd1 standard conditions Long-pec whole organism WB
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-actn WB WT control Long-pec trunk musculature sarcomere
WB Day 4 trunk musculature sarcomere
WB WT + MO1-pyroxd1 + MO2-pyroxd1 standard conditions Long-pec trunk musculature sarcomere
WB Day 4 trunk musculature sarcomere
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-pyroxd1 standard conditions Long-pec whole organism pyroxd1 expression decreased amount, abnormal
Long-pec whole organism pyroxd1 expression decreased amount, abnormal
WT + MO1-pyroxd1 + MO2-pyroxd1 standard conditions Long-pec skeletal muscle morphology, abnormal
Long-pec skeletal muscle sarcomere structure, abnormal
Long-pec thigmotaxis decreased process quality, abnormal
Long-pec whole organism pyroxd1 expression decreased amount, abnormal
Day 4 skeletal muscle broken, abnormal
Day 4 skeletal muscle morphology, abnormal
Day 4 skeletal muscle sarcomere structure, abnormal
WT + MO2-pyroxd1 standard conditions Long-pec thigmotaxis decreased process quality, abnormal
Long-pec whole organism pyroxd1 expression decreased amount, abnormal
Full text @ Am. J. Hum. Genet.