ZFIN ID: ZDB-GENE-040426-1732
Gene Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Gene Symbol: pyroxd1    Nomenclature History

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Previous Names: ryroxd1 (1), zgc:73254

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to the nucleus and sarcomere. Human ortholog(s) of this gene implicated in myofibrillar myopathy 8. Is expressed in trunk musculature. Orthologous to human PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1).
Genome Resources: Alliance (1),  Gene:393736 (1),  Ensembl(GRCz11):ENSDARG00000104817 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:73254]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7011 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pyroxd1 N/A 1
MO2-pyroxd1 N/A 1
DISEASE ASSOCIATED WITH pyroxd1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
myofibrillar myopathy 8 Alliance Myopathy, myofibrillar, 8 617258
DISEASE ASSOCIATED WITH pyroxd1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component cytoplasm (more)
Molecular Function oxidoreductase activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR023753 FAD/NAD(P)-binding domain
Homologous_superfamily IPR036188 FAD/NAD(P)-binding domain superfamily
Domain IPR041575 NADH-rubredoxin oxidoreductase, C-terminal
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-ryroxd1 WB Abmart
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pyroxd1 No data available
MARKER RELATIONSHIPS
pyroxd1 Encodes: [cDNA] MGC:73254 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_200763 (1)
Genomic GenBank:CU861460 (1) 31929 bp
Select Tool
Polypeptide UniProtKB:Q6PBT5 (1) 490 aa
Sequence Information (all 13)
ORTHOLOGY for pyroxd1 ( Chr: 4 )
CITATIONS (17)