FIGURE

Fig. S9

ID

ZDB-FIG-161221-13

Publication

Weber et al., 2016 - Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons

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Fig. S9

Eurydendroid cells are largely unaffected by PC apoptosis. Double transgenic PC-ATTAC^TM larvae crossed into Tg(olig2:egfp) background were subjected at 4dpf to 4OHT treatment to examine the effect of Purkinje cell ablation on olig2:egfp expressing green fluorescent eurydendroid cells. (A) CLSM image of right cerebellar hemisphere of 4dpf larva showed intact FyntagRFP-expressing Purkinje cells (red) and eurydendroid cell somata (green). (B and C) 4OHT-induced Purkinje cell ablation resulted in the significant reduction of FyntagRFP fluorescence over time (B) at 5dpf directly after the 16hrs of 4OHT-treatment or (C) at 6dpf 24 hours after the 4OHT-treatment was finished, respectively. Green fluorescent eurydendroid cells (ECs) instead were not affected by the Purkinje cell ablation over the whole duration of observation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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