ZFIN ID: ZDB-FIG-160812-3
Kim et al., 2014 - Developmental roles of D-bifunctional protein-A zebrafish model of peroxisome dysfunction. Molecules and cells   37(1):74-80 Full text @ Mol. Cells
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Protruding-mouth

Fig. 4

dbp knockdown affects development of blood, blood vessels and digestive organs. Embryos carrying different transgenes were used to determine tissue-specific effects upon dbp knockdown. (A-D) dbp knockdown affects red blood cell development and blood vessel patterning. Upon dbp knockdown, blood cells were severely reduced [shown by gata1:RFP transgenic line, (A) and (B)] and blood vessels were formed abnormally [shown by fli1:EGFP, (C) and (D)]. (E-H) dbp knockdown on doubly transgenic fish line (lfabp: DSRED in liver and elastase:GFP in pancreas) shows significantly reduced liver size (F) and absence of pancreas (H). Representative embryos at 3 dpf are shown in lateral view with anterior to the left, except (G) and (H) where presented in lateral view with anterior to the right.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
gz15Tg + MO1-hsd17b4 standard conditions Protruding-mouth liver decreased size, abnormal
Protruding-mouth pancreas absent, abnormal
ko05Tg + MO1-hsd17b4 standard conditions Protruding-mouth nucleate erythrocyte decreased amount, abnormal
y1Tg + MO1-hsd17b4 standard conditions Protruding-mouth branching involved in blood vessel morphogenesis disrupted, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Molecules and cells for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Mol. Cells