|ZFIN ID: ZDB-FIG-150421-8|
Adult cftr mutants undergo severe pancreatic destruction. (A and B) Transverse section of (A) WT and (B) cftrpd1049 mutant pancreas expressing ela:GFP in acinar cells. (C and D) Transverse section of 3 month post fertilization (mpf) WT and cftr mutant pancreas stained for insulin and glucagon to mark the pancreatic islets. (E–H) Hematoxylin and eosin staining of WT and cftr mutant pancreatic sections at (E and F) 3 mpf and (G and H) 1 year post fertilization. (I and J) Period Acid Schiff staining of 3 mpf transverse sections of the pancreas indicating mucus within the lumen of the pancreatic duct. Arrows indicate dilated pancreatic ducts. ib: intestinal bulb, p: pancreas, l: liver. Scale bars=50 µm.
ZFIN wishes to thank the journal Developmental Biology for permission to reproduce figures from this article.
Please note that this material may be protected by copyright.
Reprinted from Developmental Biology, 399(2), Navis, A., Bagnat, M., Loss of cftr function leads to pancreatic destruction in larval zebrafish, 237-48, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.