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ZFIN ID: ZDB-FIG-150313-2
Irion et al., 2014 - Gap junctions composed of connexions 41.8 and 39.4 are essential for colour pattern formation in zebrafish. eLIFE   4:1225-38 Full text @ Elife
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 5

Complete loss of the pigment pattern in double mutants of nac, pfe, and shd with leotK3.

Mutants lacking one pigment cell type, nac (A and A′), pfe (C and C′), and shd (E and E′), only form remnants of the pigmentation pattern. In nac mutants fields of dense iridophores covered with compact xanthophores (corresponding to light stripes) and loose iridophores (corresponding to dark stripes) are discernible as patches (A′). In homozygous double mutants leotK3;nac (B) the regions of dense iridophores covered by compact xanthophores expand at the expense of blue iridophore areas. In pfe mutants (C) in the absence of xanthophores the melanophores form patches in the regions around the first light stripe but are increasingly more disorganized at some distance to it (C′). In double mutants of pfe with homozygous leotK3 melanophores are distributed almost evenly as individual cells over the flank of the fish (D). In shd mutants (E), where no iridophores are present, melanophores and xanthophores only partly form the first light and dark stripes (E′). In double homozygous double mutants leotK3;shd this residual pattern is lost and only very few individual melanophores are left on the flank of the fish (F).

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
csf1ratm236b/tm236b standard conditions Adult melanophore stripe patchy, abnormal
Adult melanophore stripe spotted, abnormal
Adult xanthophore absent, abnormal
csf1ratm236b/tm236b; gja5bdtk3/dtk3 standard conditions Adult melanocyte disorganized, abnormal
Adult melanocyte dispersed, abnormal
Adult melanophore stripe spotted, abnormal
Adult xanthophore absent, abnormal
gja5bdtk3/dtk3; ltkj9s1/j9s1 standard conditions Adult iridophore absent, abnormal
Adult melanocyte dispersed, abnormal
Adult melanophore stripe absent, abnormal
gja5bdtk3/dtk3; mitfaw2/w2 standard conditions Adult iridophore irregular spatial pattern, abnormal
Adult melanocyte absent, abnormal
Adult pigmentation disrupted, abnormal
ltkj9s1/j9s1 standard conditions Adult iridophore absent, abnormal
Adult melanophore stripe spotted, abnormal
mitfaw2/w2 standard conditions Adult melanocyte absent, abnormal
Adult pigmentation disrupted, abnormal
Acknowledgments:
ZFIN wishes to thank the journal eLIFE for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Elife